![]() Cell 160:62–73įelger JC, Treadway MT (2017) Inflammation effects on motivation and motor activity: role of dopamine. Yan Y, Jiang W, Liu L et al (2015) Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Front Oncol 8:430īeaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Cancer Cell 21:822–835įinotello F, Eduati F (2018) Multi-omics profiling of the tumor microenvironment: paving the way to precision immuno-oncology. Cancer Cell 25:846–859īayne LJ, Beatty GL, Jhala N et al (2012) Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Ries CH, Cannarile MA, Hoves S et al (2014) Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Liu Q, Liao Q, Zhao Y (2017) Chemotherapy and tumor microenvironment of pancreatic cancer. Oettle H, Neuhaus P, Hochhaus A et al (2013) Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. Neoptolemos JP, Palmer DH, Ghaneh P et al (2017) Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Kamisawa T, Wood LD, Itoi T et al (2016) Pancreatic cancer. This study uncovers the reciprocal interactions between TAMs and pancreatic cancer cells using multi-omics techniques and presents that DA has synergistic roles with chemotherapy for pancreatic cancer by suppressing of TAM-derived inflammations. Further studies found that activation of DRD4 by DA led to the decrease of cAMP, and then inhibited the activation of PKA/p38 signal pathway, which suppressed the tumor-promoting inflammation of TAMs. DA substantially improved the chemotherapeutic efficacy both in vitro study and in immunocompetent murine pancreatic cancer models by suppression of the M2 characters of TAMs. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and TAMs. Herein, the roles and mechanisms of DA to affect the chemotherapeutic efficacy for pancreatic cancer were studied. However, its roles in TAMs of pancreatic cancer have not been reported. Dopamine (DA) has been reported to suppress inflammations. In this study, transcriptomics and proteomics analyses were performed to explore the interactions between murine pancreatic cancer cells and TAMs. TAMs have complicated interactions with pancreatic cancer cells, however, the details and mechanisms remain largely unknown. She was selected to the Edward Merker Lectureship in Translational Endocrinology by the Mount Sinai School of Medicine, New York.Pancreatic cancer is an inflammatory malignancy, and tumor-associated macrophages (TAMs) are the predominant inflammatory cells in tumor tissue. The University of Cincinnati awarded her the Rieveschl Award for Outstanding Scientific Research. She has also been elected as a Fellow of the AAAS, and the Fellow of the Royal Society of Medicine. In 1992, she was elected chairman of the Gordon Research Conference on Prolactin. Dr Ben-Jonathan has served on many journal editorial boards and committees of scientific societies, reviewed manuscripts for dozens of journals. She has also been studying adipose tissue and human obesity. More recently her focus has shifted to the role of hormones and signaling pathways in breast cancer and head and neck cancer. She trained as a neuro-endocrinologist and endocrine physiologist and has focused her studies on prolactin, dopamine, endocrine disruptors, and other hormones as they affect brain, pituitary, and peripheral tissues, using cells, animal models and human tissues. She has published over 175 scholarly papers and reviews, edited a book – Catecholamines as Hormone Regulators – and contributed 14 chapters to medical textbooks and encyclopedias. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule.ĭr Nira Ben-Jonathan is Professor of Cancer Biology and Internal Medicine at the University of Cincinnati Medical School. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders.
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